![]() This failure in ventilation may be caused by depression of the central respiratory center by cerebral disease or drugs, inability to ventilate adequately due to neuromuscular disease (e.g., myasthenia gravis, amyotrophic lateral sclerosis, Guillain–Barré syndrome, muscular dystrophy), or airway obstruction related to asthma or chronic obstructive pulmonary disease (COPD) exacerbation.Ĭhronic respiratory acidosis may be secondary to many disorders, including COPD. In acute respiratory acidosis, the PaCO 2 is elevated above the upper limit of the reference range (over 6.3 kPa or 45 mm Hg) with an accompanying acidemia (pH 30 mEq/L).Īcute respiratory acidosis occurs when an abrupt failure of ventilation occurs.Respiratory acidosis can be acute or chronic. ![]() The increase in PaCO 2 in turn decreases the HCO 3 −/ PaCO 2 ratio and decreases pH. Alveolar hypoventilation thus leads to an increased PaCO 2 (a condition called hypercapnia). ![]() Respiratory acidosis is a state in which decreased ventilation ( hypoventilation) increases the concentration of carbon dioxide in the blood and decreases the blood's pH (a condition generally called acidosis).Ĭarbon dioxide is produced continuously as the body's cells respire, and this CO 2 will accumulate rapidly if the lungs do not adequately expel it through alveolar ventilation. Intensive care medicine, pulmonology, internal medicine
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